Notch Signalling: Receptor cis-Inhibition To Achieve Directionality
نویسندگان
چکیده
منابع مشابه
Notch Signalling: Receptor cis-Inhibition To Achieve Directionality
Lateral inhibition, by which single cells become distinct from their neighbours, can be mediated by Notch signalling during animal development. Signalling directionality is presumably achieved by downregulation of the Notch ligand in signal-receiving cells. New evidence suggests that cis-inhibition of the receptor in the ligand-sending cell might also provide directionality.
متن کاملMechanism and Significance of cis-Inhibition in Notch Signalling
Notch receptors in a given cell are activated by cell surface ligands in neighbouring cells but can also be inhibited by the ligands present within the same cell. This process is known as cis-inhibition of Notch. Additionally, reciprocal cis-inhibition of the ligands by Notch has also been observed, albeit to a limited extent. Here, we review the mechanisms, functional relevance and potential i...
متن کاملA Role of Receptor Notch in Ligand cis-Inhibition in Drosophila
Notch and its ligands mediate short-range cell interactions that play a conserved role in inducing cell fate specification. Several regulatory mechanisms have been described to ensure robust polarized signaling from signal-sending to signal-receiving cells. High levels of ligand expression activate Notch in nearby cells and exert a cell-autonomous dominant-negative effect on Notch activity. Thi...
متن کاملInhibition of notch signalling ameliorates experimental inflammatory arthritis.
OBJECTIVE To test the hypothesis that Notch signalling plays a role in the pathogenesis of rheumatoid arthritis (RA) and to determine whether pharmacological inhibition of Notch signalling with γ-secretase inhibitors can ameliorate the RA disease process in an animal model. METHODS Collagen-induced arthritis was induced in C57BL/6 or Notch antisense transgenic mice by immunisation with chicke...
متن کاملDishevelled limits Notch signalling through inhibition of CSL
Notch and Wnt are highly conserved signalling pathways that are used repeatedly throughout animal development to generate a diverse array of cell types. However, they often have opposing effects on cell-fate decisions with each pathway promoting an alternate outcome. Commonly, a cell receiving both signals exhibits only Wnt pathway activity. This suggests that Wnt inhibits Notch activity to pro...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Current Biology
سال: 2009
ISSN: 0960-9822
DOI: 10.1016/j.cub.2009.07.025